B cell repertoire viral response study published in Frontiers in Immunology

As part of the BBSRC-funded project we have analysed B cell repertoires from infections with SARS-CoV-2, Ebola, and RSV, and reported distinct and unique antiviral antibody responses across pandemic, epidemic, and endemic viruses. We focused specifically on clonal expansions, gene usage, somatic hypermutation and class-switch recombination patterns across these different immune challenges. We also contributed a new R package named BrepPhylo for building clonal lineage trees from antibody repertoire data.Very fruitful collaboration with the lab of Deborah Dunn-Walters at University of Surrey.

Read the paper on Frontiers in Immunology.